It can be physiological (typically widespread and transient, more marked in neonates and infants), primary (persistent, due to a continuous vasospasm of arterioles when secondary aetiologies are ruled out) or secondary. 3 The reticulate pattern usually has a red–blue or violaceus hue, and hyperpigmentation is not frequent (which helps to distinguish it from EAI). It is important to rule out other reticular disorders, such as livedo reticularis, which is a temperature-sensitive vasculopathy that favours the extremities. It is important to monitor patients who present with EAI and report long-term exposure to heat, as prolonged heat exposure can predispose to the future development of cutaneous squamous cell carcinoma or Merkel cell carcinoma. It is advised to ask about prior localised pain, as the use of heat might be a sign of suboptimal pain management. Management consists of the cessation of the offending heat source. If performed, epidermal atrophy and dermal melanophages are often observed. It is characteristically asymptomatic, although a slight burning sensation can be noted. 1 Clinically, it begins as areas of localised reversible reticulated erythema that reflect the areas of venous predominance in the skin, identical to livedo reticularis, and evolves into a fixed reticulated hyperpigmentation in the same pattern. This condition is known as erythema ab igne (EAI), which is a disorder caused by local chronic exposure to low levels of infrared heat below the threshold for a thermal burn (eg after contact with heating pads, hot water bottles, laptop computers). What differential diagnoses should be considered? Answer 3 Only a slight hyperpigmented network persisted two months later. She was prescribed a betamethasone dipropionate cream 0.05% twice a day for 14 days and was advised to avoid heat sources. Neither biopsy indicated vasculitis or thrombotic vasculopathy. The biopsy from the reticulated patch showed epidermal atrophy, whereas the other was unspecific. The patient acknowledged that, during the previous three months, she had been using a hot water bottle, held between her thighs, to warm herself while in bed.Īlthough not required for the diagnosis, two 4-mm punch biopsies were taken from one of the reticulated patches on the patient’s left thigh and the unaffected area between the patches to evaluate the integrity of the arterial skin supply due to her COVID-19 diagnosis and to rule out vasculitis or vasculopathy. Answer 2Ī history of chronic heat exposure should be sought. The lesions consisted of dusky hyperpigmented reticulated patches, with superimposed pink keratotic plaques on the inner thighs and legs. What history specific to the clinical appearance would you take? Answer 1 How would you describe the lesions? Question 2 Proximal and distal arterial pulses were present.įigure 1. Reticulated erythematous and hyperpigmented patches on both inner thighs and legsįigure 2. On the inner right leg, reticulated linear erythematous plaques were present Laboratory tests were unremarkable, apart from a mildly elevated C-reactive protein level (13 mg/L, reference range <6 mg/L). She had been referred to a dermatologist by her general practitioner (GP), who had suspected COVID-19-associated livedo reticularis and had prescribed acetylsalicylic acid 100 mg once daily. The lesions developed five days after the onset of an episode of fever, cough and malaise, and the patient was diagnosed with a mild case of COVID-19 due to a positive real-time reverse transcription–polymerase chain reaction for SARS-CoV-2 that had been taken from a nasopharyngeal swab. She complained of a slightly pruritic rash that had started to appear 10 days earlier (Figures 1 and 2). A woman aged 52 years presented to the emergency department in Madrid, Spain, in December 2020 during the COVID-19 pandemic.
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